clobenpropit

Clobenpropit is a potent small molecule antagonist/inverse agonist of the histamine H3 receptor and a partial agonist of the histamine H4 receptor. It also inhibits the chemokine receptor CXCR4, showing potential activity in autoimmune conditions and cancer through immunomodulation. In animal models, clobenpropit has demonstrated neuroprotective effects, modulates neurotransmitter release, and shows potential for symptom control in conditions like systemic lupus erythematosus (SLE). Clobenpropit is used primarily in research and has not been approved for clinical use[1][3][4]. Its main investigational use is in mechanistic studies of histaminergic and chemokine pathways, and there is active research into its potential therapeutic applications in autoimmune diseases and malignancies[1][3][4].

Other names

N-(4-chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea