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clobetasol propionate + ammonium lactate
- Development stage
- Unknown
- Lead developer
- Canbro Healthcare
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Clobetasol propionate + ammonium lactate is a topical combination drug used primarily for the treatment of inflammatory and hyperkeratotic skin conditions. Clobetasol propionate is a potent synthetic corticosteroid that acts by suppressing inflammation and immune responses in the skin through inhibition of pro-inflammatory mediators such as prostaglandins. Ammonium lactate is an alpha-hydroxy acid derivative that functions as both a moisturizer and keratolytic agent; it increases skin hydration by promoting water retention in the stratum corneum and helps to soften and remove rough or scaly skin. This combination provides both anti-inflammatory effects (from clobetasol) and enhanced moisturization/keratolysis (from ammonium lactate), making it effective for short-term management of severe or steroid-responsive dermatoses such as psoriasis, eczema, ichthyosis vulgaris, chronic dry/scaly skin disorders, lichen planus, contact dermatitis, and other similar conditions[1][2][3][6][9].
- Brand names
- COVATE SOFTLacsoft C GelTopinate-ALBariderm-ALCortico ALIsorvate-ALNuvate AL
- Other names
- clobetasol + ammonium lactate
02
Targets
GR (Glucocorticoid receptor)
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