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Drug intelligence / Profile preview
clobetasol propionate + miconazole nitrate
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Clobetasol propionate + miconazole nitrate is a combination topical pharmaceutical containing a **potent corticosteroid** (clobetasol propionate) and an **imidazole antifungal** (miconazole nitrate)[1][5][9]. Clobetasol propionate works by binding to glucocorticoid receptors within skin cells, reducing expression of pro-inflammatory mediators and decreasing vasodilation, capillary permeability, and leukocyte migration, leading to relief of inflammation, itching, redness, and swelling[2][5]. Miconazole nitrate acts by disrupting fungal cell membrane synthesis (inhibiting ergosterol formation), causing leakage and death of fungal cells[1][5]. This combination is used primarily in dermatology to treat inflammatory skin conditions where fungal infection is present or suspected, including **eczema**, **dermatitis**, **psoriasis**, and other mixed inflammatory/fungal dermatoses[5][9].
- Other names
- clobetasol+miconazoleclobetasol propionate+miconazole nitrate
02
Targets
CYP51A1 (Sterol 14α-demethylase)KatGGR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)
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