clodronate

Clodronate is a first-generation bisphosphonate used to treat conditions involving excessive bone resorption, such as hypercalcemia of malignancy, osteolytic bone metastases, osteoporosis in postmenopausal women, and Paget’s disease. It works primarily by inhibiting osteoclast-mediated bone resorption. The drug binds strongly to hydroxyapatite crystals in the bone matrix at sites of increased turnover and disrupts the function and survival of osteoclasts—specialized cells responsible for breaking down bone tissue. Mechanistically, after being released from the bone during resorption, it is taken up by osteoclasts where it can be metabolized into non-hydrolyzable ATP analogues that inhibit mitochondrial ADP/ATP translocase activity, leading to apoptosis of these cells. Clodronate also exhibits anti-inflammatory properties and has been used off-label for conditions like complex regional pain syndrome (CRPS), rheumatoid arthritis, and other inflammatory or painful musculoskeletal disorders[1][2][3][4][5][6][7].

Brand names

ClasteonBonefosOstac

Other names

clodronic acidclodronate disodiumdisodium clodronatesodium clodronate