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clodronic acid
- Development stage
- Unknown
- Lead developer
- Bioprojet
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Clodronic acid is a first-generation, non-nitrogen-containing bisphosphonate used primarily for the management of hypercalcemia and osteolysis associated with malignant tumors, such as breast cancer and multiple myeloma. Developed and marketed by companies including Bioprojet (under the brand name Clastoban), it acts by inhibiting bone resorption. Unlike nitrogen-containing bisphosphonates (e.g., zoledronic acid), clodronic acid is metabolized within osteoclasts into a non-hydrolyzable analog of adenosine triphosphate (ATP), specifically adenosine 5'-(beta,gamma-dichloromethylene)triphosphate (AppCp). This metabolite accumulates and inhibits mitochondrial ATP/ADP translocase, leading to osteoclast apoptosis and a subsequent reduction in bone turnover. It is available in both oral and intravenous formulations.
- Brand names
- ClastobanBonefosLoronOstac
- Other names
- clodronateclodronate disodiumdisodium clodronate
02
Targets
ANT1/2/3 (Mitochondrial ADP/ATP translocase)VNUT (Vesicular nucleotide transporter)
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