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clomiphene + metformin + n-acetylcysteine
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination of three medications potentially used for treating polycystic ovary syndrome (PCOS), particularly in clomiphene-resistant patients. The combination includes clomiphene citrate (an ovulation inducer), metformin (an insulin-sensitizing agent), and N-acetyl cysteine (a mucolytic agent with antioxidant properties). While studies have compared two-drug combinations (clomiphene+metformin versus clomiphene+N-acetyl cysteine), the provided search results do not contain evidence on using all three medications simultaneously as a single therapeutic approach.
- Other names
- clomiphene citrate + metformin + n-acetylcysteineclomiphene + metformin + NAC
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ER (Estrogen receptor)ND1 (Mitochondrial electron transport chain complex I)MUC5B (Mucin-5B)
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