clomiphene citrate + prednisolone

A combination therapy used primarily for treating anovulatory infertility, particularly in patients who are resistant to clomiphene citrate alone. This combination therapy has shown promising results in inducing ovulation and achieving pregnancy in women with conditions such as polycystic ovary syndrome (PCOS) and premature ovarian failure. The regimen typically consists of extended clomiphene citrate (100-150 mg daily for 7 days) and low-dose prednisolone (5 mg daily). This combination has shown high rates of ovulation (73%) and pregnancy (46%) in clomiphene-resistant patients, offering a potential alternative before proceeding to more expensive and risky treatments like gonadotropin stimulation or surgery.