clomiphene citrate + urofollitropin

Clomiphene citrate + urofollitropin is a combination therapy used in the management of female infertility, particularly for ovulation induction and controlled ovarian stimulation. Clomiphene citrate is an orally administered selective estrogen receptor modulator (SERM) that stimulates the release of gonadotropins (FSH and LH) from the pituitary by blocking estrogen receptors in the hypothalamus, leading to increased follicular development and ovulation[4][6][7][8]. Urofollitropin is a purified form of human follicle-stimulating hormone (FSH), typically administered via subcutaneous injection, which directly stimulates ovarian follicular growth[5]. This combination may be used sequentially or together in women who do not respond adequately to clomiphene alone or as part of assisted reproductive technologies such as in vitro fertilization. The primary indication is for women with anovulatory infertility, including those with polycystic ovary syndrome.

Other names

clomiphene citrate + uFSHCC + uFSHclomiphene citrate co-treatment with urinary FSHsequential CC and uFSH