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clomipramine + lithium carbonate
- Development stage
- Preclinical
- Lead developer
- Novartis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination of clomipramine, a tricyclic antidepressant, and lithium carbonate, a mood stabilizer. This combination has been studied for treatment-resistant depression. Clomipramine works primarily by inhibiting serotonin reuptake, while lithium carbonate is thought to enhance serotonin neurotransmission when used as an augmentation strategy.
02
Targets
SERT (Sodium-dependent serotonin transporter)HTR1B (5-Hydroxytryptamine Receptor 1B)NET (Norepinephrine Transporter)
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