clonidine + fentanyl (Columbia University)

The drug name **clonidine + fentanyl-Columbia University-labor pain** refers to a clinical research comparison conducted by Columbia University (NCT01846221) evaluating two different epidural analgesic combinations for the management of breakthrough pain during advanced labor. The study specifically compared epidural clonidine (75–100 μg) combined with bupivacaine versus epidural fentanyl (75–100 μg) combined with bupivacaine. Clonidine is an alpha-2 adrenergic receptor agonist that provides non-opioid analgesia, while fentanyl is a potent mu-opioid receptor agonist. The trial aimed to determine if clonidine was superior for treating the somatic component of pain in the late first or second stages of labor. Results from the Phase 4 trial indicated that both regimens provided similar analgesic efficacy and had comparable hemodynamic side effect profiles, suggesting that clonidine is an effective alternative to fentanyl in this setting.

Other names

Clonidine vs Fentanyl for Breakthrough Labor Pain