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Clopenthixol is a typical antipsychotic drug of the thioxanthene class, introduced in 1961. It acts primarily as an antagonist at Dopamine receptor D1 and Dopamine receptor D2, similar to phenothiazine antipsychotics. Clopenthixol is used for the treatment of schizophrenia and other psychoses. The drug was developed by Lundbeck[3]. It is composed of a mixture of cis- and trans-isomers; its cis-isomer is known as zuclopenthixol, which has separate clinical use[3][4]. Clopenthixol's mechanism involves blocking dopamine receptors in the brain to reduce psychotic symptoms[2][3].
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