Drug intelligence / Profile preview

clopenthixol

Development stage
Unknown
Lead developer
Lundbeck
Modality
Small Molecules
Administration
Oral, Intramuscular
01

Overview

Clopenthixol is a typical antipsychotic drug of the thioxanthene class, introduced in 1961. It acts primarily as an antagonist at Dopamine receptor D1 and Dopamine receptor D2, similar to phenothiazine antipsychotics. Clopenthixol is used for the treatment of schizophrenia and other psychoses. The drug was developed by Lundbeck[3]. It is composed of a mixture of cis- and trans-isomers; its cis-isomer is known as zuclopenthixol, which has separate clinical use[3][4]. Clopenthixol's mechanism involves blocking dopamine receptors in the brain to reduce psychotic symptoms[2][3].

Brand names
SordinolCiatyl
Other names
clopentixol
02

Targets

5-HT2 (5-HT2 receptor family)ADRA2A (α2A)DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)ADRA1A (α1A)mAChR (Muscarinic acetylcholine receptors)HRH1 (Histamine H1 Receptor)

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