cloprostenol isopropyl ester

Cloprostenol isopropyl ester is a synthetic small molecule analog of prostaglandin F2α (PGF2α) and a potent agonist of the FP (prostaglandin F) receptor. As a more lipid-soluble isopropyl ester prodrug of the optically active (+)-cloprostenol, it exhibits enhanced membrane permeability compared to its parent acid. In veterinary medicine, it has been investigated for its potent luteolytic properties to synchronize estrus and manage reproductive cycles in livestock, demonstrating significantly higher potency than natural PGF2α in terminating pregnancy in animal models. Research has also explored its potential in human medicine for the reduction of intraocular pressure in patients with glaucoma and ocular hypertension. It is primarily available as a research chemical and does not have a widely recognized commercial brand name for human therapeutic use.

Other names

(+)-cloprostenol isopropyl ester15(R)-cloprostenol isopropyl estercloprostenol isopropyl ester (15R)