cloridarol

Cloridarol is a benzofuran derivative that was historically developed and marketed as a coronary vasodilator for the treatment of coronary insufficiency and angina pectoris. It is characterized by its myocardiotrophic action and was typically administered orally at dosages such as 750 mg/day. Recent scientific interest has focused on repurposing cloridarol as an inhibitor of human islet amyloid polypeptide (hIAPP) aggregation. Research suggests it binds to the C-terminal β-sheet region of hIAPP oligomers through hydrophobic interactions and hydrogen bonding, potentially protecting islet β-cells from toxicity associated with Type 2 Diabetes.

Brand names

Menacor

Other names

2-benzofuryl-p-chlorophenyl-carbinol(2-benzofuranyl)(4-chlorophenyl)methanolCloridarolo