Drug intelligence / Profile preview

closantel

Development stage
Unknown
Lead developer
Aarambh Life Science
Modality
Small Molecules
Administration
Oral, Subcutaneous
01

Overview

Closantel is a salicylanilide small molecule anthelmintic primarily used in veterinary medicine to treat parasitic infections in livestock such as cattle, sheep, and goats. It is particularly effective against trematodes, including the liver fluke *Fasciola hepatica*, as well as certain nematodes like *Haemonchus contortus* and arthropod larvae. The drug exerts its antiparasitic effect by uncoupling oxidative phosphorylation in the mitochondria of the parasite, which disrupts ATP production and leads to metabolic exhaustion and death. Aarambh Life Science manufactures closantel as a generic active pharmaceutical ingredient (API) in both base and sodium salt forms for use in various veterinary formulations.

Other names
Closantel SodiumClosantel Base
02

Targets

SDH (Mitochondrial electron transport chain complex II)CHIT1 (Chitotriosidase)

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