Drug intelligence / Profile preview

Closebax SD

Development stage
Unknown
Lead developer
Synchroline
Modality
Small Molecules
Administration
Topical
01

Overview

Closebax SD is a topical dermocosmetic product line developed by Synchroline (a brand of General Topics s.r.l.) specifically designed for the management of seborrheic dermatitis and severe dandruff. The formulation is available in various forms, including a shampoo and a cream, and utilizes a multi-targeted approach to address the underlying causes of seborrheic conditions. It typically contains a combination of antifungal agents such as **climbazole** and **piroctone olamine**, which inhibit the growth of *Malassezia* yeast, a primary contributor to seborrheic dermatitis. Additionally, it incorporates **triethyl citrate** to inhibit the lipase enzymes that break down sebum into irritating fatty acids, **zinc lactate** for sebum regulation, and **salicylic acid** for its keratolytic properties to facilitate the removal of scales and crusts. The product aims to reduce inflammation, itching, and desquamation while restoring the scalp's natural balance.

Brand names
Closebax SD
02

Targets

GehA (Triacylglycerol lipase GehA)CYP51A1 (Sterol 14α-demethylase)

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