Closol

Closol is a topical pharmaceutical product brand for **clobetasol propionate**, a superpotent synthetic corticosteroid used for inflammatory and pruritic dermatoses such as psoriasis, eczema, dermatitis, lichen planus, and related allergic or inflammatory skin disorders. It is a **small-molecule steroid** formulated for external use in dosage forms including ointment, cream, lotion, foam, and spray, typically at 0.05% strength. Clobetasol exerts anti-inflammatory, antipruritic, and vasoconstrictive effects primarily through activation of the glucocorticoid receptor, leading to altered gene transcription and induction of phospholipase A2 inhibitory proteins that suppress downstream production of inflammatory mediators including prostaglandins and leukotrienes.

Brand names

Closol

Other names

clobetasol propionateclobetasol