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clostridia, cluster XIVa, strain relative Clostridium_q symbiosum, live

Development stage: Unknown
Lead developer: Vedanta Biosciences
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Clostridia, cluster XIVa, strain relative Clostridium_q symbiosum, live is a defined live commensal bacterial strain used as an active component of Vedanta Biosciences' orally administered microbiome therapeutics. The strain is identified in the VE303 program as VE303-04 and is also listed under the synonyms VE202-16 and JNJ-64841946. It is incorporated into the eight-strain VE303 live biotherapeutic product being evaluated for prevention of recurrent *Clostridioides difficile* infection, and it has also been included in the larger VE202 bacterial consortium evaluated for mild-to-moderate ulcerative colitis. The intended pharmacology is restoration of colonization resistance and beneficial gut microbial metabolism rather than binding to a single human molecular target. ([ctis.eu](https://ctis.eu/trial/2022-502972-22-00))

Other names: clostridia, cluster XIVa, strain relative Clostridium_q symbiosum, live

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