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clostridium butyricum + lactobacillus
- Development stage
- Unknown
- Lead developer
- Miyarisan Pharmaceutical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
This combination probiotic therapy consists of *Clostridium butyricum* and *Lactobacillus* species (most commonly *Lactobacillus acidophilus*). *Clostridium butyricum* is a gram-positive, anaerobic, spore-forming bacterium that produces butyric acid, a short-chain fatty acid (SCFA) essential for the health of colonocytes and the maintenance of the intestinal epithelial barrier. *Lactobacillus* species are lactic acid-producing bacteria that lower intestinal pH, thereby inhibiting the growth of pathogenic bacteria and stimulating local mucosal immunity. Together, these organisms work synergistically to restore gut microbiota balance, enhance the intestinal barrier, and prevent the translocation of bacteria into the bloodstream. This is particularly relevant for immunocompromised patients, such as those undergoing chemotherapy for head and neck cancers, where intestinal damage can lead to repeated sepsis.
- Brand names
- Bio-ThreeLacbonMiyarisan
- Other names
- Clostridium butyricum and Lactobacillus acidophilus combined capsulesClostridium butyricum and Lactobacillus acidophilusC. butyricum + Lactobacillus
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