CloSYS Oral Rinse

CloSYS Oral Rinse is a topical antimicrobial mouth rinse developed by Rowpar Pharmaceuticals, primarily utilizing stabilized chlorine dioxide (ClO2) as its active ingredient. Marketed under the trade name Clorastan, it acts as a broad-spectrum oxidizing agent that disrupts and penetrates dental biofilms to eliminate microbial pathogens, including bacteria and viruses. While traditionally used for oral hygiene and conditions like gingivitis and oral malodor, it was investigated during the COVID-19 pandemic for its potential to reduce SARS-CoV-2 viral load in the oral cavity. In vitro studies demonstrated significant reduction in viral load, leading to Phase 2 clinical trials aimed at lowering transmission, though the FDA issued a warning regarding unapproved COVID-19 treatment claims.

Brand names

CloSYSClōSYSCloSYS Ultra Sensitive Oral Rinse

Other names

Stabilized Chlorine DioxideClorastan