Drug intelligence / Profile preview

clotrimazole + beclomethasone + gentamicin

Development stage
Unknown
Lead developer
Glenmark Pharmaceuticals
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, RNA-Targeting Small Molecules → Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Topical
01

Overview

This is a combination topical pharmaceutical containing three active ingredients: **clotrimazole**, an imidazole-class broad-spectrum antifungal that damages fungal cell membranes causing leakage and cell death; **gentamicin**, an aminoglycoside antibiotic that inhibits bacterial protein synthesis, resulting in bacterial cell death; and **beclomethasone**, a synthetic glucocorticoid corticosteroid that reduces inflammation by suppressing prostaglandin synthesis. This formulation is indicated for the treatment of mixed fungal and bacterial skin infections, including dermatitis, eczema, psoriasis, impetigo, diaper rash, lichen simplex, bug bites, burns, boils, dermatoses, and otitis externa. It is for **topical administration only** and should not be used on open wounds, blisters, or mucosal surfaces without medical supervision[2].

02

Targets

CYP51A1 (Sterol 14α-demethylase)Bacterial RibosomeGR (Glucocorticoid receptor)

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