Drug intelligence / Profile preview

clotrimazole + betamethasone

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
Administration
Topical
01

Overview

**Clotrimazole + betamethasone** is a topical combination drug consisting of clotrimazole, an imidazole-class antifungal, and betamethasone, a synthetic corticosteroid. The antifungal component inhibits fungal growth by disrupting cell membrane synthesis, while the corticosteroid reduces inflammation by suppressing various mediators of the immune response. This drug is indicated primarily for fungal skin infections—such as tinea corporis (ringworm), tinea cruris (jock itch), and tinea pedis (athlete's foot)—particularly when accompanied by significant inflammation[1][2][3][7][10]. It is not effective against bacterial or viral infections. The combination is supplied predominantly as a topical cream or lotion and is intended for short-term use due to the risk of corticosteroid-related adverse effects[2][3][7].

Brand names
Lotrisone
Other names
clotrimazole-betamethasoneclotrimazole and betamethasone dipropionatebetamethasone and clotrimazole topical
02

Targets

CYP51A1 (Sterol 14α-demethylase)GR (Glucocorticoid receptor)

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