clotrimazole + Lactobacillus (Peking University Shenzhen Hospital)

This combination therapy consists of the antifungal agent clotrimazole and a probiotic supplement containing human reproductive tract active Lactobacillus. It is being evaluated as an adjuvant treatment for recurrent vulvovaginal candidiasis (RVVC). Clotrimazole is a synthetic imidazole antifungal that works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, leading to increased membrane permeability and cell death. The addition of oral Lactobacillus is intended to restore the natural vaginal microbiota balance, which is often disrupted in women with recurrent infections. By recolonizing the reproductive tract, Lactobacillus species compete with *Candida* for nutrients and adhesion sites, produce antimicrobial substances like lactic acid and hydrogen peroxide, and modulate the local immune response to prevent the recurrence of fungal overgrowth.

Other names

clotrimazole vaginal tablets + Lactobacillusclotrimazole + oral LactobacillusL-Peking University Shenzhen Hospital-recurrent vulvovaginal candidiasis