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Drug intelligence / Profile preview
clotrimazole + sulfisoxazole
- Development stage
- Unknown
- Lead developer
- Cardiotech Pharmaceutical
- Modality
- Small Molecules
- Administration
- Vaginal
01
Overview
BioVagin is a combination drug product containing the antifungal agent clotrimazole and the sulfonamide antibacterial agent sulfisoxazole. It is formulated as a vaginal cream or vaginal suppository (ovule) for the treatment of vulvovaginal infections, including vulvovaginal candidiasis (moniliasis) caused by *Candida albicans*, trichomoniasis caused by *Trichomonas vaginalis*, and other mixed bacterial infections caused by susceptible Gram-positive and Gram-negative microorganisms. Clotrimazole acts by inhibiting fungal lanosterol 14-alpha demethylase, thereby disrupting ergosterol synthesis and compromising cell membrane integrity. Sulfisoxazole acts as a competitive inhibitor of dihydropteroate synthase (DHPS), blocking bacterial folic acid synthesis.
- Brand names
- BioVaginClodizol PlusVagil
- Other names
- clotrimazol + sulfisoxazolclotrimazol + sulfisoxazoleclotrimazole + sulfisoxazol
02
Targets
CYP51A1 (Sterol 14α-demethylase)CYP5218 (Cytochrome P450 5218)DHPS (Dihydropteroate synthase)
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