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cloxacillin
- Development stage
- Phase 3
- Lead developer
- GSK
- Modality
- Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Intravenous, Intramuscular
01
Overview
Cloxacillin is a semisynthetic penicillin antibiotic used primarily to treat infections caused by beta-hemolytic streptococci, pneumococci, and staphylococci—including those that produce beta-lactamase. It is a chlorinated derivative of oxacillin and belongs to the class of penicillinase-resistant penicillins. Cloxacillin works by binding to specific penicillin-binding proteins (PBPs) inside the bacterial cell wall, thereby inhibiting the final stage of bacterial cell wall synthesis. This leads to cell lysis mediated by autolytic enzymes such as autolysins[1][5][8]. It is effective against gram-positive organisms, especially *Staphylococcus aureus*[8].
- Brand names
- JAMP-CloxacillinTEVA-Cloxacillin
- Other names
- cloxacilin
02
Targets
PBP (Penicillin-binding protein family)
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