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clusterin siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
Clusterin siRNA is a small interfering RNA designed to silence the expression of the clusterin (CLU) gene. Clusterin is a multifunctional chaperone protein involved in various physiological and pathological processes, including apoptosis, cell cycle regulation, and DNA repair. In oncology research, clusterin siRNA is frequently used to sensitize cancer cells (such as prostate, cervical, and leukemia cells) to chemotherapeutic agents like paclitaxel by inhibiting the anti-apoptotic and pro-survival functions of secreted clusterin. It is also utilized in studies of endoplasmic reticulum (ER) stress and renal disease to elucidate the signaling pathways mediated by clusterin.
- Other names
- CLU siRNAsmall interfering RNA targeting clusterin
02
Targets
CLU (Clusterin)
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