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CLZ-3001

Development stage
Preclinical
Lead developer
Cellatoz Therapeutics
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

CLZ-3001 is an autologous natural killer cell therapy developed by Cellatoz Therapeutics for cancer treatment. The product consists of homogenized NK cells engineered or manufactured to highly express CD16 on the cell surface, with the intended mechanism of enhancing **CD16-mediated antibody-dependent cellular cytotoxicity** against tumor cells and potentially acting synergistically with immuno-oncology agents. Publicly described development has focused on neoplasms including ovarian cancer, with broader interest in solid tumors and possible exploration in glioblastoma; the program has been described as suitable for repeat dosing and aimed at restoring immune balance rather than simply transiently activating effector cells.

Other names
16ENKsCD16-highly expressing natural killer cellsCD-16-highly expressing natural killer cellsCD 16-highly expressing natural killer cells
02

Targets

FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)

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