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CM-BA-9
- Development stage
- Phase 1
- Lead developer
- Liangyou Gu
- Modality
- Cell Therapies
- Administration
- Intratumoral
01
Overview
CM-BA-9 is an investigational chimeric antigen receptor macrophage (CAR-M) cell therapy targeting carbonic anhydrase IX (CA9). Developed by Liangyou Gu, it is designed for the treatment of unresectable or metastatic clear cell renal cell carcinoma (ccRCC). CA9 is a cell-surface protein highly overexpressed in ccRCC. CM-BA-9 consists of autologous or donor-derived macrophages genetically engineered to express a CAR targeting CA9, which enables them to specifically recognize and phagocytose CA9-expressing tumor cells, secrete pro-inflammatory cytokines, and remodel the immunosuppressive tumor microenvironment. It is administered via intratumoral injection.
- Other names
- CA9-targeted CAR-MCA-9-targeted CAR-MCA 9-targeted CAR-MCA9-targeted chimeric antigen receptor macrophage therapyCA-9-targeted chimeric antigen receptor macrophage therapyCA 9-targeted chimeric antigen receptor macrophage therapy
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