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CM583
- Development stage
- Preclinical
- Lead developer
- Keymed Biosciences
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
CM583 is a long-acting bispecific monoclonal antibody being developed by Keymed Biosciences for the treatment of migraine. It is designed to simultaneously target and inhibit two key neuropeptides involved in migraine pathophysiology: Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP). By dual-targeting these pathways, CM583 aims to provide superior efficacy in migraine prevention compared to existing therapies that target only the CGRP pathway. The drug has reached the Investigational New Drug (IND) application stage, marking its transition into clinical evaluation.
02
Targets
Calcitonin gene-related peptide type 1 receptorPAC1R (Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor))
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