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CMGV

Development stage: Preclinical
Lead developer: Ruijin Hospital
Modality: Nanoparticles → Drug Delivery Systems, Recombinant Proteins and Enzymes, Small Molecules
Administration: Intravenous, Oral, Subcutaneous

Overview

**CMGV** is an investigational multi-agent treatment regimen comprising liposomal mitoxantrone hydrochloride, cytarabine, granulocyte colony-stimulating factor, and venetoclax. It is being evaluated by Ruijin Hospital in a prospective multicenter study for recurrent adult acute myeloid leukemia, myelodysplastic syndrome with increased blasts, and older adult acute myeloid leukemia. The regimen combines DNA-damaging and antimetabolite chemotherapy with granulocyte colony-stimulating factor-mediated myeloid stimulation and venetoclax-mediated B-cell lymphoma 2 inhibition to promote leukemic-cell apoptosis.

Other names: CMG + venetoclaxCMG+VenCMGV regimenmitoxantrone hydrochloride liposome + cytarabine + G-CSF + venetoclax

Targets

DNA polymerase familyBCL-2 (BCL-2 family)CSF3R (Granulocyte colony-stimulating factor receptor)TOP2A (DNA topoisomerase II)

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