CN54ENV

CN54ENV is a DNA plasmid vaccine candidate designed to elicit an immune response against the Human Immunodeficiency Virus Type 1 (HIV-1). It specifically encodes the gp140 envelope (Env) glycoprotein derived from the HIV-1 clade C 97CN54 strain. The vaccine utilizes a plasmid vector to deliver the genetic sequence of the viral antigen into host cells—typically through intramuscular or intradermal injection, often enhanced by electroporation. Once inside the cells, the host machinery expresses the HIV-1 Env protein, which is then presented to the immune system to stimulate the production of neutralizing antibodies and activate T-cell responses. CN54ENV is frequently investigated as a priming agent in heterologous prime-boost vaccination strategies, used in conjunction with viral vectors like Modified Vaccinia Ankara (MVA-C) or recombinant protein boosts (such as CN54rgp140) to achieve broader and more potent immunity against HIV-1 clade C, which is prevalent in sub-Saharan Africa and China.

Other names

HIV DNA-C CN54ENVCN54ENV DNACN-54ENV DNACN 54ENV DNADNA-C CN54ENV plasmid DNA