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CN54ENV DNA vaccine + interleukin-12 plasmid DNA
- Development stage
- Unknown
- Lead developer
- Imperial College London
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular, Intradermal
01
Overview
CN54ENV is an HIV-1 DNA vaccine candidate developed by Ichor Medical Systems in collaboration with Imperial College London. The vaccine consists of a DNA plasmid encoding the HIV-1 envelope glycoprotein (gp140) derived from the 97CN54 clade C isolate. It is designed to be delivered via intramuscular or intradermal electroporation using Ichor's TriGrid Delivery System (TDS-IM) to enhance cellular uptake and immunogenicity. In clinical study regimens, the vaccine may be co-administered with an interleukin-12 (IL-12) plasmid DNA adjuvant to further boost immune responses and may include a subsequent protein boost with recombinant CN54gp140. The primary goal is to elicit both humoral and cellular immune responses against the HIV envelope protein.
- Other names
- CN54ENV DNA vaccineCN-54ENV DNA vaccineCN 54ENV DNA vaccineCN54ENV DNA vaccine + IL-12 plasmid DNACN54ENV DNA vaccine + interleukin-12 plasmid DNA-Ichor Systems
02
Targets
gp140 (HIV-1 gp140)
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