Drug intelligence / Profile preview

CN54gp140 + GLA-AF

Development stage: Unknown
Lead developer: St. George's University of London
Modality: Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

CN54gp140 + GLA-AF is a combination vaccine formulation consisting of a recombinant HIV envelope protein (CN54gp140) and a synthetic adjuvant (GLA-AF). CN54gp140 is a soluble, trimeric form of the HIV envelope from the C/B' strain 97/CN/54, expressed in CHO cells. GLA-AF (Glucopyranosyl Lipid Adjuvant-Aqueous Formulation) is a synthetic hexaacylated lipid A derivative that acts as a TLR-4 agonist. This combination has been used in HIV vaccine clinical trials, typically administered intramuscularly at a dosage of 100 μg CN54gp140 with 5 μg GLA-AF.

Other names: CN54gp140 HIV vaccineCN-54gp140 HIV vaccineCN 54gp140 HIV vaccine97CN54gp140HIV-1 clade C envelope protein vaccineHIV1 clade C envelope protein vaccineHIV 1 clade C envelope protein vaccine

Targets

TLR4 (Toll-like receptor 4)

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