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Drug intelligence / Profile preview
CNC-ala-17-E2
- Development stage
- Preclinical
- Lead developer
- German Cancer Research Center
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
CNC-ala-17-E2 is an experimental hormone-linked nitrosourea designed for the targeted treatment of breast cancer. It consists of a cytotoxic nitrosourea moiety, 1-(2-chloroethyl)-1-nitrosocarbamoyl-L-alanine (CNC-ala), covalently linked to estradiol at the 17-position. This design aims to utilize the estrogen receptor (ER) to selectively deliver the DNA-alkylating nitrosourea to ER-positive tumor cells, thereby increasing local concentration and reducing systemic toxicity. Research has demonstrated its activity in various preclinical models, including MXT mammary carcinoma in mice and MNU-induced mammary carcinoma in rats, although its efficacy in human primary breast carcinoma samples in vitro has shown variability.
- Other names
- 1-(2-chloroethyl)-1-nitrosocarbamoyl-L-alanine-estradiol-17-esterCNC-L-Ala-estradiol-17-esterCNC-L-Ala-estradiol17-esterCNC-L-Ala-estradiol 17-ester
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