Drug intelligence / Profile preview

CNP-TPT

Development stage
Preclinical
Lead developer
SiNON Nano Sciences
Modality
Small Molecules, Nanoparticles → Drug Delivery Systems
01

Overview

**CNP-TPT** is a preclinical carbon-nanoparticle formulation of the small-molecule chemotherapy agent topotecan being developed by SiNON Nano Sciences for cancer. The carbon nanoparticle carrier is intended to encapsulate topotecan and improve delivery, stability, controlled release, and therapeutic exposure. Topotecan inhibits DNA topoisomerase I by stabilizing the topoisomerase I-DNA cleavage complex and preventing DNA strand re-ligation, leading to replication-associated DNA damage and tumor-cell death. ([sinontx.com](https://sinontx.com/product/cnp-arg-copy-2/))

Other names
Topotecan encapsulated in Carbon Nano Particles

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