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CNR-100
- Development stage
- Preclinical
- Lead developer
- Canurta Therapeutics
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
01
Overview
CNR-100 is a preclinical-stage botanical therapy being developed by Canurta Therapeutics for the treatment of chronic inflammatory conditions, including rheumatoid arthritis, juvenile arthritis, and respiratory diseases. Derived from rare hemp-derived prenylated flavonoids, specifically cannflavins A and B, using the proprietary PolyKye™ Platform, CNR-100 acts as a dual-pathway inhibitor. It simultaneously targets microsomal prostaglandin E synthase-1 (mPGES-1) and arachidonate 5-lipoxygenase (5-LO), thereby blocking the production of both proinflammatory prostaglandins and leukotrienes.
- Other names
- CNR-100sCNR100sCNR 100s
02
Targets
ALOX12 (Arachidonate 12-lipoxygenase, 12S type)PTGES (Microsomal prostaglandin E synthase-1)
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