co-amoxiclav

Co-amoxiclav (Bristol Laboratories) is a combination antibiotic oral suspension containing amoxicillin trihydrate and potassium clavulanate. Amoxicillin is a beta-lactam antibiotic that exerts its bactericidal activity by binding to and inhibiting penicillin-binding proteins (PBPs), which are essential for bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor that structurally resembles beta-lactam antibiotics; it binds irreversibly to beta-lactamase enzymes produced by resistant bacteria, preventing them from inactivating amoxicillin. This combination extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to it and other beta-lactam antibiotics. It is indicated for the treatment of various bacterial infections, including acute bacterial sinusitis, skin and soft tissue infections, and bone and joint infections.

Brand names

Co-amoxiclav Oral Suspension Sugar-Free

Other names

amoxicillin + clavulanic acidamoxicillin trihydrate + potassium clavulanate