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Co-Mekina is a combination intranasal spray developed and marketed by Daewoong Pharmaceutical for the symptomatic relief of acute rhinitis and allergic rhinitis. The formulation typically contains xylometazoline hydrochloride, a sympathomimetic agent that acts as an alpha-adrenergic agonist to induce vasoconstriction in the nasal mucosa, and chlorpheniramine maleate, a first-generation antihistamine that antagonizes H1 receptors. By combining these two active ingredients, the spray provides rapid relief from nasal congestion, sneezing, and rhinorrhea associated with the common cold or hay fever. It is positioned as a fast-acting over-the-counter (OTC) treatment for upper respiratory symptoms.
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