coagulation factor ix

Coagulation factor IX is a protein essential for normal blood clotting and hemostasis. It is produced in the liver and circulates in the bloodstream in an inactive form until activated by injury. Upon activation (to Factor IXa), it interacts with Factor VIIIa to form a complex that activates Factor X—an integral step in the blood coagulation cascade[3][5][6][8]. Pharmaceutical forms of this drug include both plasma-derived and recombinant products; recombinant versions are produced using genetically engineered cell lines (such as CHO cells) to replicate human Factor IX[3]. Coagulation factor IX is primarily indicated for the treatment and prevention of bleeding episodes in patients with hemophilia B (congenital Factor IX deficiency or Christmas disease)[1][2][4]. It does not treat hemophilia A or other clotting disorders.

Brand names

BenefixIxinityRixubisIdelvionAlphaNine SDAlprolix

Other names

factor ixrecombinant coagulation factor ixhuman coagulation factor ix