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coagulation factor IX human
- Development stage
- Approved
- Lead developer
- Grifols
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Coagulation Factor IX Human is a purified protein derived from human plasma that plays a critical role in the blood clotting cascade. It is essential for hemostasis and normal blood clotting as it acts as a zymogen (inactive enzyme precursor) that is activated by Coagulation Factor XIa to become an active serine protease. Once activated (Factor IXa), it forms a complex with calcium ions, membrane phospholipids, and Coagulation Factor VIII to activate Coagulation Factor X—an integral step in the formation of fibrin clots. Deficiency of this protein causes hemophilia B (Christmas disease). Therapeutic preparations are used intravenously to treat or prevent bleeding episodes in patients with hemophilia B by temporarily replacing deficient or missing endogenous Factor IX[1][3][5][6].
- Brand names
- Alphanine SdBalfaxarBeriplexImmunine VhKcentraOctaplex
- Other names
- factor ix humanchristmas factorcoagulation factor ix (human)alphaNine SD
02
Targets
Coagulation Factor IXa
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