coagulation factor IXa recombinant

**Coagulation factor IXa recombinant** is a recombinant form of activated human coagulation factor IX, a serine protease in the intrinsic coagulation cascade. In physiology, factor IXa complexes with activated factor VIII on phospholipid surfaces in the presence of calcium to form the intrinsic tenase complex, which activates factor X to factor Xa and thereby amplifies thrombin generation and fibrin clot formation. As a therapeutic concept, recombinant factor IX products are well established for hemophilia B, but marketed products are generally recombinant factor IX zymogen rather than activated recombinant factor IXa specifically; therefore the query most likely refers to an activated mechanistic form or a nonstandard/experimental designation rather than a clearly marketed standalone drug product.

Other names

recombinant factor IXarecombinant activated factor IXactivated coagulation factor IX recombinantcoagulation factor IXa recombinant