coagulation factor VIIa

Coagulation factor VIIa is a recombinant or plasma-derived form of the naturally occurring activated Factor VII protein in humans. It is a serine protease enzyme that plays a critical role in the extrinsic pathway of the coagulation cascade by binding to tissue factor at sites of vascular injury and activating factors IX and X. This leads to thrombin generation and clot formation. Recombinant forms (eptacog alfa and eptacog beta) are used as bypassing agents for treating or preventing bleeding episodes in patients with hemophilia A or B who have developed inhibitors to factors VIII or IX. They are also indicated for congenital Factor VII deficiency and may be used off-label for other severe bleeding disorders[1][2][3][4][5][6][8].

Brand names

NovoSevenNovoSeven RTSevenfactNiastase RT

Other names

recombinant activated factor VIIrFVIIablood-coagulation factor VIIaactivated blood coagulation factor VII