coagulation factor VIII + von Willebrand factor

Coagulation factor VIII + von Willebrand factor is a plasma-derived biologic combination product used for the treatment and prevention of bleeding in patients with hemophilia A and von Willebrand disease (VWD). It consists of human coagulation factor VIII (FVIII) and von Willebrand factor (VWF) purified from human plasma. In the bloodstream, VWF acts as a carrier protein for FVIII, protecting it from premature degradation and increasing its half-life. This combination is particularly useful in patients with severe hemophilia A who have developed inhibitors, where it is used in immune tolerance induction (ITI) protocols, and in patients with VWD where both factors are deficient or dysfunctional. The product supplements the deficient activity of these proteins in the coagulation cascade.

Brand names

Humate-PHaemate PWilateAlphanateVoncento

Other names

FVIII/VWF concentrateFactor VIII/von Willebrand Factor Complex (Human)