Drug intelligence / Profile preview

coal tar + ketoconazole

Development stage
Unknown
Lead developer
Percos
Modality
Small Molecules
Administration
Topical
01

Overview

Protar K (also marketed as Protar-K Solution or Protar-K Lotion) is a topical combination therapy developed by Percos for the treatment of scalp conditions such as dandruff, seborrheic dermatitis, and scalp psoriasis. It is formulated as a topical solution or lotion containing 4% w/v coal tar and 2% w/v ketoconazole. Ketoconazole is an imidazole antifungal agent that inhibits the synthesis of ergosterol, a key component of fungal cell membranes, thereby stopping the growth of dandruff-causing fungi like Malassezia. Coal tar is a keratolytic and keratoplastic agent that slows down rapid skin cell turnover, facilitates the shedding of dead skin cells from the scalp's top layer, and relieves itching and flaking.

Brand names
Protar KProtar-KProtar-K LotionProtar-K Solution
Other names
ketoconazole + coal tar
02

Targets

AHR (Aryl hydrocarbon receptor)CYP3A4 (Cytochrome P450 3A4)CYP51A1 (Sterol 14α-demethylase)

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