cobalt protoporphyrin

Cobalt protoporphyrin (CoPP) is a synthetic metalloporphyrin and a potent small molecule inducer of heme oxygenase-1 (HO-1). It exerts its pharmacological effects by binding to and inactivating the transcriptional repressor Bach1, thereby facilitating the expression of HO-1 through the Nrf2 (nuclear factor erythroid 2-related factor 2) and Bach1 signaling pathways. The induction of HO-1 leads to the enzymatic degradation of heme into biliverdin, carbon monoxide, and free iron, which collectively mediate robust antioxidant, anti-inflammatory, and cytoprotective responses. Preclinical research has investigated CoPP for its therapeutic potential in diverse conditions, including ischemia/reperfusion injury, cholestatic liver disease, viral infections (such as influenza), and obesity. Currently, CoPP is utilized exclusively as an experimental tool compound in laboratory research and is not approved for clinical use in humans.

Other names

cobalt protoporphyrin IXcobaltic protoporphyrin IXCo-protoporphyrinCo-protoporphyrin IXCAS 14325-03-2CAS14325-03-2CAS-14325-03-2