cobotide

Cobotide is a polypeptide drug derived from the venom of the Chinese cobra (*Naja naja atra*), specifically a modified neurotoxin. It functions as an antagonist of nicotinic acetylcholine receptors (nAChRs), including the alpha-7 subtype (α7-nAChR), which plays a critical role in pain transmission and neuroinflammation. Developed and studied primarily at Xiangya Hospital, Central South University, Cobotide is utilized as an analgesic for chronic pain and is currently being evaluated in observational clinical trials for its potential neuroprotective and neurorehabilitative effects in patients with neurodegenerative diseases. The drug is assessed for its impact on pain sensitivity and neurological response using clinical scales and quantitative sensory testing, exploring its synergy with neurorehabilitation through network pharmacology and bioinformatics analyses.

Other names

考博肽cobra venom peptide