cobratoxin

Cobratoxin is a 71-amino acid long-chain post-synaptic neurotoxin isolated from the venom of the Thailand cobra (*Naja kaouthia*). It functions as a high-affinity, reversible antagonist of nicotinic acetylcholine receptors (nAChRs), specifically targeting the alpha-7 (α7) and muscle-type (α1β1δε) subtypes. While naturally a potent paralytic agent, chemically modified or detoxified versions of the peptide, such as **RPI-78M**, are being developed for therapeutic applications. These modified forms retain neuromodulatory, anti-inflammatory, and analgesic properties without the systemic toxicity of the raw venom. Clinical development has primarily focused on neurodegenerative and autoimmune conditions, including **adrenomyeloneuropathy (AMN)** and **multiple sclerosis (MS)**, where the drug is thought to modulate immune responses and provide neuroprotection. It has also been investigated for potential use in chronic kidney disease and as an antiviral agent.

Brand names

Nyloxin

Other names

alpha-cobratoxinα-cobratoxinCobrotoxinThailand cobra venom neurotoxin