CocoaVia

CocoaVia is a dietary supplement containing cocoa flavanols, specifically investigated by Stanford University in a clinical trial (NCT03123068) for its potential to modulate the surgical immune response. The supplement is intended to be administered preemptively (5 days before surgery) to attenuate the surgery-evoked increase in High Mobility Group Box 1 (HMGB1) plasma levels and Nuclear Factor-kappa B (NF-κB) signaling in innate immune cells. By targeting the HMGB1-NFκB signaling axis, the treatment aims to reduce systemic inflammation and improve patient-centered recovery outcomes following major orthopedic procedures such as hip or knee arthroplasty. The product is manufactured by Mars and contains standardized levels of cocoa bean extract.

Brand names

CocoaVia

Other names

CocoaVia-Stanford Universitycocoa flavanolscocoa bean extract