codeine + diclofenac

Codeine + diclofenac is a combination analgesic drug consisting of codeine, an opioid analgesic, and diclofenac, a nonsteroidal anti-inflammatory drug (NSAID). This combination is used for the management of moderate to severe pain where both inflammatory and nociceptive components are present. Codeine acts primarily as a prodrug that is metabolized to morphine in the body, exerting its effect by agonizing mu-opioid receptors in the central nervous system to reduce pain perception and induce sedation[5][8]. Diclofenac inhibits cyclooxygenase (COX)-1 and COX-2 enzymes, leading to decreased synthesis of prostaglandins involved in inflammation and pain signaling[3]. The combination may provide superior analgesia compared with either agent alone but can increase the risk of side effects such as gastrointestinal irritation (from diclofenac) or respiratory depression (from codeine)[1][5].

Other names

codeine and diclofenacdiclofenac and codeinediclofenac + codeine