codeine + promethazine

**Codeine + promethazine** is a combination drug commonly used in oral syrup or solution form for the temporary relief of cough and upper respiratory symptoms associated with allergies or the common cold[1][5][6]. **Promethazine** is a first-generation antihistamine of the phenothiazine class that works by blocking H1 histamine receptors, reducing symptoms like sneezing, runny nose, and congestion. It also has antidopaminergic, anticholinergic, and sedative properties. **Codeine** is a natural opioid that acts as an agonist at mu-opioid receptors in the central nervous system, suppressing the cough reflex and providing mild analgesic effects[1][3][12]. The combination is indicated for adults and not recommended for children under 18 due to risk of respiratory depression and other serious adverse events[6]. This product is available only by prescription.

Brand names

Phenergan with Codeine

Other names

promethazine and codeinepromethazine/codeinepromethazine + codeine