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codeine phosphate in sirupus simplex
- Development stage
- Unknown
- Lead developer
- UZ Leuven
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Codeine phosphate in sirupus simplex is an oral liquid formulation of the opioid analgesic codeine, being investigated by Universitaire Ziekenhuizen KU Leuven for its effects on esophageal motility. Codeine acts as an agonist at mu-opioid receptors in the central nervous system and the gastrointestinal tract. In the context of esophageal motility research, codeine has been shown to increase resistance at the esophagogastric junction and alter distal esophageal motility patterns. The formulation uses sirupus simplex (simple syrup), a pharmaceutical vehicle consisting of sugar and water, to deliver the active ingredient, codeine phosphate.
- Other names
- siripus simplex-Universitaire Ziekenhuizen KU Leuven-esophageal motility disordercodeine phosphate syrupcodeine phosphate in simple syrup
02
Targets
MOR (Mu opioid receptor)KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)
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